Virus-Host Cell interactions

Viruses are considered as entities at the border of the definition of life, and yet they are woven in every aspect of our natural world. Unfortunately, viruses are also major biological infectious agents that cause various acute and chronic infectious diseases.

Our research group is investigating, at the molecular level, the interactions between viruses and their host cells. As obligatory intracellular parasites, viruses relay on the machinery, metabolism, and energy sources of their host cells. Also, to initiate an infectious cycle that eventually results in the production of progeny virions, viruses must transfer their genetic information across the host cellular membranes. Therefore, a thorough understanding of the interactions between viruses and their host cells is critical for the understanding of infectious diseases, treatments, and prevention.

In our lab, we utilize structural biology together with molecular, biochemical and biophysical approaches to study how viruses specifically bind and enter to the host cells and how the host’s immune system recognize and neutralize the viruses, and apply this knowledge to the development of therapeutics and prophylactic vaccines for better treatment and prevention of infectious disease

Our current work is focused on the Hepatitis C virus (HCV) and the recently emerged SARS-CoV-2

       

The Tzarum lab is now hiring

We are now hiring a lab manager, MSc/PhD students, and postdocs.
 
If you are enthusiastic
about basic research with
life-saving applications, 
please send your C.V.
and a cover letter 
to
Netanel.Tzarum@mail.huji.ac.il 

From the news  

Enlistment of the Academy to support the community during the Corona crisis                                                                                                                          (by Netanel Tzarum)

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