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From structural studies to HCV vaccine design

I. Yechezkel, M. Law, N. Tzarum.  Viruses 13 (5), 833  (2021).


Functional convergence of a germline-encoded neutralizing antibody response in rhesus macaques immunized with HCV envelope glycoproteins

F. Chen*, N. Tzarum*, X. Lin, E. Giang, R. Velazquez-Moctezuma, E. H. Augestad, K. Nagy, L. He, M. Hernandez, M. E. Fouch, A. Grinyo, D. Chavez, B. J. Doranz, J. Prentoe, R. L. Stanfield, R. Lanford, J. Bukh, I. A. Wilson, J. Zhu, M. Law. Immunity. 54, 781-796 (2020).

An alternate conformation of HCV E2 neutralizing face as a new vaccine target

N. Tzarum, E. Giang, R. U. Kadam, F. Chen, K. Nagy, E. H. Augestad, R.  Velázquez-Moctezuma, Z.Y. Keck, Y. Hua, R. L. Stanfield, M. Dreux,

J.Prentoe, S. K. H. Foung, J. Bukh, I. A. Wilson, M. Law. Science Advances. 6, eaav5642 (2020).

Proof-of-concept for rational design of hepatitis C virus E2 core nanoparticle vaccine

L. He*, N. Tzarum*, X. Lin, B. Shapero, C. Sou, C. J. Mann, A. Stano, L. Zhang, K. Nagy, E. Giang, M. Law, I. A. Wilson, J. Zhu. Science Advances. 6, eaav6225 (2020).


N-Glycolylneuraminic acid as a receptor for influenza A viruses                    

F. Broszeit, N. Tzarum, X. Zhu, N. Nemanichvili, D. Eggink, T. Leenders, Z. Li, L. Liu, M. A. Wolfert, A. Papanikolaou, C. Martinez-Romero, I. A. Gagarinov, W. Yu, A. Garcia-Sastre, T. Wennekes, M. Okamatsu, M. H. Verheije, I. A. Wilson, G. J. Boons, R. P. de Vries. Cell Report, 27, 3284-3294 e3286 (2019).   

VH1-69 antiviral broadly neutralizing antibodies: genetics, structures, and relevance to rational vaccine design    

F. Chen*, N. Tzarum*, I. A. Wilson, M. Law. Current Opinion in Virology, 34, 149-159 (2019). 


Genetic and structural insights into broad neutralization of hepatitis C virus by human VH1-69 antibodies                  

N. Tzarum, E. Giang, L. Kong, L. He, J. Prentoe, E. Augestad, Y. Hua, S. Castillo, G. M. Lauer, J. Bukh, J. Zhu, I. A. Wilson, M. Law. Science Advances, 5, eaav1882 (2019).                                                  



immunogenetic and structural analysis of a class of HCV broadly neutralizing antibodies and their precursors 

F. Aleman,* N. Tzarum*, L. Kong, K. Nagy, J. Zhu, I. A. Wilson, M. Law  Proc. Natl. Acad. Sci. U.S.A. 115, 7569-7574 (2018). 

The Neutralizing Face of Hepatitis C Virus E2 Envelope Glycoprotein

N. Tzarum, I. A. Wilson, M. Law. Frontis in immunology, 9, 1315 (2018).   


Probing the antigenicity of hepatitis C virus envelope glycoprotein complex by high-throughput mutagenesis

R. Gopal, K. Jackson, N. Tzarum, L. Kong, A. Ettenger, J. Guest, J. M. Pfaff, T. Barnes, A. Honda, E. Giang, E. Davidson, I. A. Wilson, B. J. Doranz, M. Law. PLoS Pathogen. 13, e1006735 (2017).

A single mutation in Taiwanese H6N1 influenza hemagglutinin switches binding to human-type receptors

R. P. de Vries*, N. Tzarum*, W. Peng*, A. J. Thompson*, I. N. Ambepitiya Wickramasinghe, A. T. T. de la Pena, M. J. van Breemen, K. M. Bouwman, X. Zhu, R. McBride, W. Yu, R. W. Sanders, M. H. Verheije, I. A. Wilson, J. C. Paulson. EMBO Molecular Medicin. 9, 1314-1325 (2017).

Unique structural features of influenza virus H15 hemagglutinin

N. Tzarum, R. McBride, C. M. Nycholat, W. Peng, J. C. Paulson, I. A. Wilson. J. Virol. 91,  (2017).

The 150-loop restricts the host specificity of human H10N8 influenza virus

N. Tzarum, R. P. de Vries, W. Peng, A. J. Thompson, K. M. Bouwman, R. McBride, W. Yu, X. Zhu, M. H. Verheije, J. C. Paulson, I. A. Wilson. Cell Reports. 19, 235-245 (2017).


Structural flexibility at a major conserved antibody target on hepatitis C virus E2 antigen

L. Kong, D. E. Lee, R. U. Kadam, T. Liu, E. Giang, T. Nieusma, F. Garces, N. Tzarum, V. L. Woods, Jr., A. B. Ward, S. Li, I. A. Wilson, M. Law. Proc. Natl. Acad. Sci. U.S.A. 113, 12768-12773 (2016).

HMGB1 activates proinflammatory signaling via TLR5 leading to allodynia

N. Das, V. Dewan, P. M. Grace, R. J. Gunn, R. Tamura, N. Tzarum, L. R. Watkins, I. A. Wilson, H. Yin. Cell Report. 17, 1128-1140 (2016).


A human-infecting H10N8 influenza virus retains a strong preference for avian-type receptors

H. Zhang*, R. P. de Vries*, N. Tzarum*, X. Zhu, W. Yu, R. McBride, J. C. Paulson, I. A. Wilson. Cell Host and Microbe. 17, 377-384 (2015).

Structure and receptor binding of the hemagglutinin from a human H6N1 influenza virus

N. Tzarum, R. P. de Vries, X. Zhu, W. Yu, R. McBride, J. C. Paulson, I. A. Wilson. Cell Host and Microbe. 17, 369-376 (2015).

                       The last two papers were highlighted  with a preview by the journal editor

                       H10N8 and H6N1 Maintain Avian Receptor Binding

                       M. Richard and R.A.M. Fouchier, Cell Host and Microbe. 17, 292-294 (2015)

Before 2015

DEF pocket in p38alpha facilitates substrate selectivity and mediates autophosphorylation

N. Tzarum, N. Komornik, D. Ben Chetrit, D. Engelberg, O. Livnah. Journal of Biological Chemistry. 288, 19537-19547 (2013).

Lipid molecules induce p38alpha activation via a novel molecular switch

N. Tzarum*, Y. Eisenberg-Domovich*, J. J. Gills, P. A. Dennis, O. Livnah. Journal of Molecular Biology. 424, 339-353 (2012).

Conformational bias imposed by source microseeds results in structural ambiguity.

N. Tzarum, D. Engelberg, O. Livna. Acta Crystallogr. F 67, 877-884 (2011).

Active mutants of the TCR-mediated p38alpha alternative activation site show changes in the phosphorylation lip and DEF site formation

N. Tzarum, R. Diskin, D. Engelberg, O. Livnah. Journal of Molecular Biology. 405, 1154-1169 (2011).

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